General Information

  • ID:  hor002488
  • Uniprot ID:  NA
  • Protein name:  GFSKLYFamide
  • Gene name:  NA
  • Organism:  Holothuria glaberrima
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GFSKLYF
  • Length:  7
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T7 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  acts as a neuromuscular transmitter or neuromodulator
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002488_AF2.pdbhor002488_ESM.pdb

Physical Information

Mass: 96820 Formula: C44H60N8O10
Absent amino acids: ACDEHIMNPQRTVW Common amino acids: F
pI: 9.3 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: 42.86 Boman Index: 273
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 55.71
Instability Index: -355.71 Extinction Coefficient cystines: 1490
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  7722004
  • Title:  Localization of the Heptapeptide GFSKLYFamide in the Sea Cucumber Holothuria Glaberrima (Echinodermata): A Light and Electron Microscopic Study